A BIOINFORMATIC APPROACH FOR THE IDENTIFICATION OF INTERACTORS OF PROTEINS INVOLVED IN GENETIC DISEASES
- 2 Years 2004/2006
- 53.900€ Total Award
Aim of the project is to develop a web accessible tool dedicated to the analysis and discovery of new functional features in proteins of known structure involved in genetic diseases. The identification of new functional sites can have as main goals: i) the identification of binding abilities (for drugs or inhibitor peptides) suited for therapeutic usage; ii) the gaining of new insights into the basic mechanisms of a genetic disease and, consequently, hints towards symptoms relief or recovery.
Scientific Publications
- 2005 BMC BIOINFORMATICS
A neural strategy for the inference of SH3 domain-peptide interaction specificity
- 2007 JOURNAL OF MOLECULAR BIOLOGY
Convergent evolution of enzyme active sites is not a rare phenomenon
- 2005 BMC BIOINFORMATICS
Functional annotation by identification of local surface similarities: a novel tool for structural genomics
- 2005 BMC BIOINFORMATICS
Query3d: a new method for high-throughput analysis of functional residues in protein structures
- 2007 BMC BIOINFORMATICS
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
- 2005 Nucleic acids research
pdbFun: mass selection and fast comparison of annotated PDB residues
- 2008 BMC BIOINFORMATICS
FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures
- 2007 Nucleic acids research
SH3-Hunter: discovery of SH3 domain interaction sites in proteins
- 2006 BIOINFORMATICS
A novel structure-based encoding for machine-learning applied to the inference of SH3 domain specificity
- 2007 Nucleic acids research
Phospho3D: a database of three-dimensional structures of protein phosphorylation sites
- 2007 Nucleic acids research
3dLOGO: a web server for the identification, analysis and use of conserved protein substructures
- 2007 BMC BIOINFORMATICS
Local comparison of protein structures highlights cases of convergent evolution in analogous functional sites
- 2005 BIOINFORMATICS
Seq2Struct: a resource for establishing sequence-structure links
