EFFECT OF PS1 GENE MUTATIONS ON BETA SECRETASE ACTIVITY, APP’S CLEAVAGE AND INDUCTION OF EARLY ONSET FAMILIAL AD PHENOTYPE.

Scientific Publications

• 2010 JOURNAL OF NEUROCHEMISTRY

  Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology

• 2002 NEUROCHEMISTRY INTERNATIONAL

  Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappa B activation

• 2004 NEUROCHEMISTRY INTERNATIONAL

  alpha-glycerylphosphorylethanolamine rescues astrocytes from mitochondrial impairment and oxidative stress induced by amyloid beta-peptides

• 2004 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  BACE1 overexpression regulates amyloid precursor protein cleavage and interaction with the ShcA adapter

• 2002 JOURNAL OF BIOLOGICAL CHEMISTRY

  Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain

• 2004 JOURNAL OF NEUROCHEMISTRY

  Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells

• 2005 BRAIN RESEARCH REVIEWS

  The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications

• 2004 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  Apoptotic cell death and amyloid precursor protein signaling in neuroblastoma SH-SY5Y cells

• 2002 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  Proteasome inhibitors induce cerebellar granule cell death - Inhibition of nuclear factor-kappa B activation

• 2002 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with She/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain