EXPLORING THE ROLE OF MITOCHONDRIAL MEMBRANES IN TRIGGERING CELL LOSS IN HUNTINGTON DISEASE: PATIENTS, ANIMAL MODELS AND MOLECULAR MECHANISMS

Huntington Disease is a neurodegenerative disease. The causal mechanisms of this disease are still unknown. We pointed to the alterations of mitochondria, the organelle that provides energy to the cells, as possible cause of clinical manifestations of the disease. The idea is to provide new therapeutic strategies aimed at the maintenance of the functional activity of mitochondria. This could also impair the cell death by self-digestion, typical cause of cell injury in HD.