A link between Toll-like Receptor signaling in dendritic cells and autoimmune manifestations in Wiskott-Aldrich syndrome

The Wiskott-Aldrich disease is a genetic syndrome that affects boys below 10 years of age. The prognosis is often very poor. Patients are not able to defend against bacterial infections and are affected by recurrent hemorrhage and hematological malignancies. In the last five years many improvements have been made to understand the molecular basis of this pathology. However, more efforts are needed to understand the role of different cells of the immune system in this syndrome. These studies will help to develop new therapeutic strategies to cure the disease.