BIOPHYSICAL MOLECULAR GENETIC AND “IN VITRO” AND “IN VIVO” PHARMACOLOGICAL STUDIES OF MYOTONIC SYNDROMES DIRECTED TOWARD THE DEVELOPMENT OF NOVEL THERAPEUTICAL APPROACHES

Scientific Publications

• 1998 BRITISH JOURNAL OF PHARMACOLOGY

  Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels

• 1997 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

  Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse

• 1998 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

  Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers

• 1998 BRITISH JOURNAL OF PHARMACOLOGY

  Effects of mexiletine on ATP sensitive K+ channel of rat skeletal muscle fibres: a state dependent mechanism of action

• 1999 NEUROMUSCULAR DISORDERS

  Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia