CLOSTRIDIAL NEUROTOXINS: MECHANISM OF ACTION AND THERAPEUTIC TREATMENT OF DISEASES OF THE NEUROMUSCULAR JUNCTION

Scientific Publications

• 2000 JOURNAL OF NEUROCHEMISTRY

  Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons

• 2001 TOXICON

  Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity

• 1999 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES

  Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses

• 1998 TOXICOLOGY LETTERS

  In vitro biological activity and toxicity of tetanus and botulinum neurotoxins

• 1998 NEUROSCIENCE LETTERS

  Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans

• 1999 JOURNAL OF NEUROCHEMISTRY

  Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes

• 2001 TOXICON

  Tetanus and botulinum neurotoxins: turning bad guys into good by research

• 2000 TRENDS IN BIOCHEMICAL SCIENCES

  How do presynaptic PLA(2) neurotoxins block nerve terminals?

• 1999 JOURNAL OF NEUROSCIENCE

  Tetanus toxin blocks the exocytosis of synaptic vesicles clustered at synapses but not of synaptic vesicles in isolated axons

• 2000 PHYSIOLOGICAL REVIEWS

  Neurotoxins affecting neuroexocytosis

• 1999 JOURNAL OF NEUROCHEMISTRY

  Botulinum neurotoxin E-insensitive mutants of SNAP-25 fail to bind VAMP but support exocytosis

• 1999 JOURNAL OF CELL SCIENCE

  Functional characterisation of tetanus and botulinum neurotoxins binding domains

• 2000 CLINICA CHIMICA ACTA

  Bacterial toxins with intracellular protease activity