MECHANISM OF ACTION OF BOTULINUM NEUROTOXINS AND TREATMENT OF SPASTIC DISORDERS WITH BOTULINUM NEUROTOXIN-DIPHTHERIA TOXIN CONJUGATES

Scientific Publications

• 1992 JOURNAL OF BIOLOGICAL CHEMISTRY

  BOTULINUM NEUROTOXINS ARE ZINC PROTEINS

• 1993 TRENDS IN BIOCHEMICAL SCIENCES

  TETANUS AND BOTULISM NEUROTOXINS - A NEW GROUP OF ZINC PROTEASES

• 1992 NATURE

  TETANUS AND BOTULINUM-B NEUROTOXINS BLOCK NEUROTRANSMITTER RELEASE BY PROTEOLYTIC CLEAVAGE OF SYNAPTOBREVIN

• 1993 JOURNAL OF BIOLOGICAL CHEMISTRY

  BOTULINUM NEUROTOXIN SEROTYPE-F IS A ZINC ENDOPEPTIDASE SPECIFIC FOR VAMP/SYNAPTOBREVIN

• 1993 JOURNAL OF NEUROCHEMISTRY

  ANTIBODIES AGAINST RAT-BRAIN VESICLE-ASSOCIATED MEMBRANE-PROTEIN (SYNAPTOBREVIN) PREVENT INHIBITION OF ACETYLCHOLINE-RELEASE BY TETANUS TOXIN OR BOTULINUM NEUROTOXIN TYPE-B

• 1992 EMBO JOURNAL

  TETANUS TOXIN IS A ZINC PROTEIN AND ITS INHIBITION OF NEUROTRANSMITTER RELEASE AND PROTEASE ACTIVITY DEPEND ON ZINC