ROLE OF OTX1 AND OTX2 GENES IN BRAIN MORPHOGENESIS AND THEIR INVOLVEMENT IN GENERATING EPILEPSY AND OTOCEPHALY

Scientific Publications

• 1999 CURRENT OPINION IN NEUROBIOLOGY

  Conserved usage of gap and homeotic genes in patterning the CNS

• 1998 EMBO JOURNAL

  Otx1 and Otx2 in the development and evolution of the mammalian brain

• 1999 DEVELOPMENT

  Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5

• 1999 TRENDS IN NEUROSCIENCES

  The TINS Lecture - Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis

• 1998 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME

  Developmental rescue of Drosophila cephalic defects by the human Otx genes

• 1999 CEREBRAL CORTEX

  Otx genes in corticogenesis and brain development

• 1998 DEVELOPMENT

  Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development

• 1998 DEVELOPMENT

  Visceral endoderm-restricted translation of Ofx1 mediates recovery of Ofx2 requirements for specification of anterior neural plate and normal gastrulation

• 1998 DEVELOPMENT

  Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH

• 1998 DEVELOPMENT

  Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila

• 1997 DEVELOPMENT

  Genetic control of brain morphogenesis through Otx gene dosage requirement

• 1999 DEVELOPMENT

  Otx1 and Otx2 activities are required for the normal development of the mouse inner ear

• 1999 GENES & DEVELOPMENT

  Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene

• 1999 MOLECULAR AND CELLULAR NEUROSCIENCE

  Otx genes and the genetic control of brain morphogenesis

• 1999 DEVELOPMENT

  Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes

• 1996 NATURE GENETICS

  Epilepsy and brain abnormalities in mice lacking the Otx1 gene

• 1996 DEVELOPMENT

  Dentate gyrus formation requires Emx2